Big powers urge Iran to heed nuclear demands

VIENNA (AP) ? Six world powers are urging Iran to heed demands aimed at easing fears that it might want nuclear arms.

The United States, Russia, China, Britain, France and Germany say it is "essential and urgent" that Iran reach an agreement with the International Atomic Energy Agency that will allow the IAEA to investigate suspicions Iran worked on such weapons.

The six say IAEA access to Parchin is particularly important. The agency has tried vainly over 18 months to visit the suspected site of weapons-related experiments.

They also said they are "deeply concerned" about Iran's enriched uranium program and a reactor that will produce plutonium when finished, in an address Wednesday to the IAEA's 35-nation board. Both can be used to make nuclear weapons.

Iran says its nuclear program is peaceful.

Source: http://news.yahoo.com/big-powers-urge-iran-heed-nuclear-demands-094548007.html

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Five-Star Match of the Week: Shawn Michaels vs. Chris Jericho - WrestleMania XIX

Shawn Michaels vs. Chris Jericho: WrestleMania 19Bret Hart and Shawn Michaels embrace: WWE.com Exclusive, May 27, 2013Bret Hart returns to WWE: WWE App Exclusive, May 27, 2013Shawn Michaels questions if John Cena is ready for his match with Curtis Axel: Raw, May 27, 2013Shawn Michaels vs. Big Boss Man: Wrestling Challenge, November 14, 1992 (Full-Length Match)Rockers vs. Demolition: Madison Square Garden, October 24, 1988 (Full-Length Match)WWE RANK'D: WWE's can't-miss WWE Championship Matches of all time

Every Wednesday, WWE Classics and Greatest Matches team up with your favorite Superstars to bring you the Five-Star Match of the Week, presented by Wrangler. We ask a Superstar in the WWE locker room to select one of the greatest wrestling matches of all time, and WWE.com brings you that full-length match, uncut.

The Miz?knows a thing or two about locking up at WrestleMania. At the 27th edition of the event, the former reality television star stunningly retained the WWE Championship against John Cena. And while Miz?s pick for a Five-Star Match of the Week didn?t close out WrestleMania XIX, it certainly left a significant impression on the future champion.

?One of my favorite matches of all time was Chris Jericho?vs. Shawn Michaels?at WrestleMania in Seattle at Safeco Field,? Miz said.

The match was HBK?s first bout on The Grandest Stage of Them All since losing the WWE Championship to ?Stone Cold? Steve Austin?at WrestleMania XIV. While a back injury kept The Showstopper from competing for years, Chris Jericho rose to prominence as one of WWE most accomplished and talented performers.?

Watch the full Austin vs. Michaels match from WrestleMania XIV

?The reason why it?s my favorite is because I enjoyed the build up toward it with the story that Chris Jericho always wanted to be Shawn Michaels,? Miz recalled. ?He dressed like Shawn Michaels, did moves like Shawn Michaels and he felt that he was better and he could beat Shawn Michaels.?

In the video clips promoting the matchup, photos of a young Y2J wearing fringed tights were paired beside a Rockers-era Michaels. Vintage footage was shown of Shawn performing a picture perfect hiptoss and other feats of athleticism, followed by Jericho performing nearly identical maneuvers.

?Not only had he become a big star like his hero,? Miz explained, ?but he also felt like he was better than his hero.??

When the time for talk was over, the two veterans laid it all out on the canvas under the bright WrestleMania lights.

See why they call HBK "Mr. WrestleMania"?|?Watch Chris Jericho's career highlights

?They put on this spectacular match that was high-flying, hard-hitting, and just everything you want in a Five-Star Match,? Miz said.

The event featured one of the most stacked lineups of all time, including iconic competitors like Austin, The Rock, Kurt Angle, Brock Lesnar, Triple H and Hulk Hogan. But most agree it was Michaels and Jericho who stole The Show of Shows. As the clash reached a zenith, each man?s arsenal had taken a significant toll on the other and HBK was finally able to reverse a suplex attempt into a roll-up for the pinfall.

?The greatest thing, in my opinion, was the ending,? Miz said. ?Shawn Michaels pins Chris Jericho, and then Jericho has this emotional moment where he?s almost crying. And you feel it. You feel the inner kid coming out of Chris Jericho. And they both go for that hug and you?re seeing this wonderful moment, and then the mean Chris Jericho comes out.??

Watch The Miz win the Intercontinental Title at WrestleMania 29

The Miz, always one to make an impression, made the point that it was what came next that defined this classic contest.

?He gives Shawn Michaels a low blow, shoves his face and walks out triumphantly,? The Awesome One recalled. ?He didn?t win, but the thing you remember from that night was Chris Jericho making you feel that emotion.?

More WWE Classics?|?Watch more full-length classic matches

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Source: http://www.wwe.com/classics/five-star-shawn-jericho-wrestlemania-xix

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Scientists find potential new clues for identifying breast cancer risk

June 4, 2013 ? New research provides critical insights into how normal breast precursor cells may be genetically vulnerable to develop into cancer. The research is published June 4th in the inaugural issue of Stem Cell Reports, an open-access journal from the International Society of Stem Cell Research (ISSCR) published by Cell Press. Scientists discovered that a particular class of normal breast precursor cells have extremely short chromosome ends (known as telomeres). As a result, these cells would be expected to be prone to acquiring mutations that lead to cancer if they managed to stay alive. These findings suggest new indicators for identifying women at higher risk for breast cancer and provide insights into potential new strategies to detect, treat, and prevent the disease.

Dr. David Gilley's laboratory at the Indiana University School of Medicine in Indianapolis and Dr. Connie Eaves' laboratory at the BC Cancer Agency's Terry Fox Laboratory in Vancouver, Canada, collaborated to determine how telomeres are regulated in different types of normal breast cells. Their studies revealed that a subset of normal breast precursor cells, called luminal progenitors, have dangerously short telomeres and display a correspondingly high level DNA damage response localized at their chromosome ends. This shows how a normal process of tissue development produces a cell type that is predisposed to acquire cancer-causing mutations.

"This is the first report of a particular normal human precursor cell type that shows such telomere malfunction," says Dr. Eaves. "The luminal progenitors we have found to possess this feature are thus now being brought into the spotlight as a likely stage where breast cancer may 'take off.'" Recent studies have implicated luminal progenitor cells in the development of breast cancers with a mutated BRCA1 gene.

The research highlights the importance of investigating different cell types in normal human tissues to understand the cellular origin of cancer and the factors that may contribute to its development. "An immediate use of our study will be to look into other human epithelial tissues to see if this finding is unique to the breast or a more general phenomenon," says Dr. Gilley.

This advance in breast cancer research reflects the mission of Stem Cell Reports to provide an open-access forum that communicates basic discoveries in stem cell research as well as translational and clinical studies. "Stem Cell Reports publishes high-quality, peer-reviewed research presenting conceptual or practical advances across the breadth of stem cell research and its applications to medicine," Christine Mummery, editor-in-chief of Stem Cell Reports says.

"The ISSCR is delighted to introduce Stem Cell Reports, an open-access forum edited by leaders in the field. Stem Cell Reports is an important complement to the ISSCR's Annual Meeting series and Regional Forums in promoting the exchange of advances and new ideas in stem cell research," says Nancy Witty, CEO of ISSCR.

"Partnering with the ISSCR in launching their first society journal, Stem Cell Reports, represents an exciting opportunity to serve the scientific community in providing high-quality stem cell research in an Open Access format. Stem Cell Reports is the second fully Open Access journal published by Cell Press and illustrates our commitment to developing new partnerships with societies across a broad range of publishing initiatives" says Emilie Marcus, CEO of Cell Press and Editor-in-Chief of Cell.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/gDaxORxyRYw/130604135405.htm

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Protester interrupts Michelle Obama at fundraiser (The Arizona Republic)

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Defense denies erotic dinners at Berusconi villa

MILAN (AP) ? Former Premier Silvio Berlusconi's defense denied Monday that there were any erotic escapades at dinners at his villa near Milan and accused the court of bias against the media mogul.

Nicolo Ghedini said during closing arguments that Berlusconi neither paid for sex with an under-age teen, nor exerted pressure on police officials in an effort to cover it up, as charged. The sensational trial is in its final stage, with a verdict is expected later this month.

Both Berlusconi and the woman, Karima el-Mahroug, who is now 20 and was 17 at the time of the alleged encounters, deny ever having had sex.

Ghedini said most prosecution witnesses who described scenes of sexual excess during the parties were not there between February 2010 and May 2010 when el-Mahroug, better known as Ruby, attended dinners at the villa. Defense witnesses described "normal" dinners during which participants chatted about soccer and denied any sexual encounters with the then-premier.

"We have 25 witnesses give more or less similar accounts of the evenings," Ghedini said, adding that prosecutors could not argue that their witnesses were correct while those of the defense who denied having sex with the premier were not reliable.

Ghedini also said the judges hearing the case "culturally similar" to prosecutors, whom he has accused of waging a politically motivated campaign against Berlusconi with the goal of removing him from politics.

"I had the impression during the course of this trial of having caused some annoyance to the judges," Ghedini said.

Berlusconi's defense has sought to move the sex trial and a tax fraud case to Brescia, another northern Italian city, arguing that Milan magistrates are biased against Berlusconi, who has faced numerous prosecutors for his business deals. Italy's high court denied the request.

An appeals court last month upheld a tax fraud conviction against Berlusconi as well as the four-year sentence and five-year ban on public office.

Neither Berlusconi nor el-Mahroug have testified at the prostitution trial, but Ghedini asked the court to enter as evidence testimony that she gave in a separate trial of three former Berlusconi aides accused of procuring prostitutes for the now infamous "bunga banga" parties at Berlusconi's villa.

In sworn testimony, el-Mahroug denied sex with Berlusconi or of witnessing sexually charged scenes. She did say she received envelopes with several thousand euros (dollars) as gifts every time she attended a party plus an additional 30,000 euros ($39,000) to open a beauty salon.

Ghedini said Berlusconi was "convinced" that el-Mahroug was related to former Egyptian president Hosni Mubarak. Berlusconi would never have discussed the young woman at a lunch with Mubarak in May 2010 if he had known she "was a minor, a Moroccan who lived in Sicily in a state of poverty and whose father was a street vendor," Ghedini said.

Prosecutors allege Berlusconi later said she was related to Mubarak only to get her released from police custody after she was accused of stealing from a roommate. Ghedini said Berlusconi telephoned an official only for information and not to seek special treatment.

Prosecutors are seeking a six-year sentence and lifetime ban from public office, a sentence Ghedini called "stratospheric and extraordinary."

Source: http://news.yahoo.com/defense-denies-erotic-dinners-berusconi-villa-135144153.html

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Does Alien Life Really Exist?

Many people believe that we're not alone in the Universe?but is that just wishful thinking, or is there a reasonable scientific basis for such a view?

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Source: http://feeds.gawker.com/~r/gizmodo/full/~3/SQ85h3SlnPY/does-alien-life-really-exist-511177270

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Next On Deck For Khan Academy: Better Diagnostics And Internationalization

Even though Sal Khan is now running a platform that serves 6 million students and people a month, he’s still churning out a couple videos a week. What’s been most recently on deck? World War I. To make a video, Khan says he’ll front-load several books worth of reading on everything from the Armistice Day to the sinking of the Lusitania. Then he’ll start to make videos once he feels he has a decent grasp on the subject material. “If I’m hanging out waiting for the dentist, I’ll just start reading something about World War I,” he said in a recent interview. From the original tutoring calls he’d arrange to help out relatives, to the initial YouTube channel he started, Khan Academy has grown to reach 75 million users to date, with 230 million lessons delivered and 1 billion problems answered in 30,000 classrooms throughout the world. Naturally, there’s been quite a bit of hype (with both its good and bad consequences). Khan Academy has the reach but it’s still proving out the data to show that its lessons measurably affect learning outcomes beyond the handful of pilots the non-profit has tried. “Teachers are rightfully skeptical, I think. They’re overworked. They have a million things to do,” Khan said. “It’s an incredibly tiring job and you’re throwing a new thing at them, even if they intellectually recognize the benefit of it.” Two of the top things on Khan’s priority list for the next fall are internationalization and diagnostics. The Khan Academy has pioneered ways of measuring progress, to help ensure that students don’t develop a “Swiss Cheese”-like base of knowledge with different weak areas. But he acknowledged the site isn’t as good at telling students where they should begin. What if they’re competent at certain things like logarithms but terribly behind in trigonometry? “One of the biggest complaints we get is that people don’t know where to start. By this August, we should have good diagnostics where people can figure out where they stand,” he said. He’s personally interested in Carol Dweck’s theories around fostering a growth-centered mentality in children and students. Her research is the basis for a series of media stories and discussions around how much you should praise children and whether you should attribute their success to persistence or innate capabilities. She’s found that children who internalize not innate talent, but rather diligence, tend to do better

Source: http://feedproxy.google.com/~r/Techcrunch/~3/Vp7PsIRmnZI/

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